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Carboxylesterase-IN-2

Carboxylesterase-IN-2 (compound 4u) is a potent inhibitor of Carboxylesterase Notum with an IC50 less than or equal to 10 nM. Notum is a negative regulator of Wnt signaling acting through the hydrolysis of a palmitoleoylate ester, which is required for Wnt activity. Carboxylesterase-IN-2 has the potential for the research of cancer disease.

Product Specifications

CAS Number

2764748-88-9

Purity

>98% (HPLC)

Solubility

In Vitro: DMSO : 50 mg/mL (183.60 mM; Ultrasonic)

Smiles

O=C1N2C (C=CC (SC3=CC (C) =C (C) C=C3) =N2) =NN1

Molecular Formula

C13H12N4OS

Molecular Weight

272.33

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

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