ML359
ML359 is a potent, selctive and reversible inhibitor of protein disulfide isomerase (PDI), with an IC50 of 250 nM. ML359 can prevent thrombus formation in vivo[1][2].
Product Specifications
CAS Number
1069858-99-6
Product Name Alternative
Nanchangmycin A,Nanchangmycin (free acid)
UNSPSC
12352005
Target
PDI
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/ml359.html
Purity
99.45
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1(CCN(CC1)CC2=CC=C(C(Cl)=C2)O)CCOC3=CC=CC=C3)OCC
Molecular Formula
C23H28ClNO4
Molecular Weight
417.93
References & Citations
[1]Khodier C, et, al. Identification of ML359 as a Small Molecule Inhibitor of Protein Disulfide Isomerase. Probe Reports from the NIH Molecular Libraries Program. 2010-2013 Apr 12.|[2]Bendapudi PK, et, al. ML359, a Small Molecule Inhibitor of Protein Disulfide Isomerase That Prevents Thrombus Formation and Inhibits Oxidoreductase but Not Transnitrosylase Activity. Blood (2014) 124 (21) : 2880.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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