ML359

ML359 is a potent, selctive and reversible inhibitor of protein disulfide isomerase (PDI), with an IC50 of 250 nM. ML359 can prevent thrombus formation in vivo[1][2].

Product Specifications

CAS Number

[1069858-99-6]

Product Name Alternative

Nanchangmycin A,Nanchangmycin (free acid)

UNSPSC

12352005

Target

PDI

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/ml359.html

Purity

99.45

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1(CCN(CC1)CC2=CC=C(C(Cl)=C2)O)CCOC3=CC=CC=C3)OCC

Molecular Formula

C23H28ClNO4

Molecular Weight

417.93

References & Citations

[1]Khodier C, et, al. Identification of ML359 as a Small Molecule Inhibitor of Protein Disulfide Isomerase. Probe Reports from the NIH Molecular Libraries Program. 2010-2013 Apr 12.|[2]Bendapudi PK, et, al. ML359, a Small Molecule Inhibitor of Protein Disulfide Isomerase That Prevents Thrombus Formation and Inhibits Oxidoreductase but Not Transnitrosylase Activity. Blood (2014) 124 (21) : 2880.