TT-012
TT-012 specifically binds to dynamic MITF and destroys the latter's dimer formation and DNA-binding ability. TT-012 inhibits the transcriptional activity of MITF in B16F10 melanoma cells. TT-012 inhibits the growth of high-MITF melanoma cells, and inhibits the tumor growth and metastasis with tolerable toxicity to liver and immune cells in animal models.
Product Specifications
CAS Number
1164471-33-3
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 100 mg/mL (286.25 mM; Ultrasonic)
Smiles
N (C (/C=C/C1=CC=CO1) =O) C=2N=C (NC (/C=C/C3=CC=CO3) =O) C=CC2
Molecular Formula
C19H15N3O4
Molecular Weight
349.34
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Available Sizes
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