DNL343
DNL343 is a brain-penetrating activator of eukaryotic initiation factor 2B (eIF2B) that inhibits the abnormal integrated stress response (ISR) . DNL343 inhibits ISR activity in the central nervous system (CNS) and reverses neurodegeneration and neuroinflammation. DNL343 also prevents motor dysfunction and premature death in eIF2B loss-of-function (LOF) mutant mice. DNL343 has inhibitory potential in studies of vanishing white matter disease (VWMD) driven by eIF2B LOF and chronic ISR activation.
Product Specifications
CAS Number
2278265-85-1
Purity
>98% (HPLC)
Smiles
N (C (COC1=CC=C (Cl) C=C1) =O) C23CC (C2) (C3) C=4OC (=NN4) [C@@H]5C[C@H] (OC (F) (F) F) C5
Molecular Formula
C20H19ClF3N3O4
Molecular Weight
457.83
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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