ADS032
ADS032 is a dual NLRP1/NLRP3 inhibitor that rapidly and reversibly blocks inflammasome formation, suppressing IL-1β and TNF-α production in human immune and epithelial cells. It reduces NLRP3-driven ASC speck formation, protects mice from lethal influenza A by dampening lung inflammation, and inhibits Nigericin-induced IL-1β secretion (IC50 = 94.6 μM, no washout; 354 μM, washout) .
Product Specifications
CAS Number
2757333-37-0
Purity
>98% (HPLC)
Solubility
DMSO : 100 mg/mL (247.81 mM; Ultrasonic)
Smiles
O=C (O) CCCC1=CC=C (C=C1) C=2C=CC (=CC2) S (=O) (=O) N (CCC) CCC
Molecular Formula
C22H29NO4S
Molecular Weight
403.54
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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