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MRK-016

MRK-016 is a potent, brain-penetrant, and orally bioavailable inverse agonist of the GABAA α5 receptor (IC50=3 nM) . It enhances hippocampal LTP in vitro and demonstrates potential for cognitive enhancement, antidepressant-like effects, and analgesia in preclinical models.

Product Specifications

CAS Number

342652-67-9

Product Name Alternative

MRK 016, MRK016, MRK-016

Field of Research

Neuroscience, Pharmacology & Drug Discovery

Purity

99.76% (May vary between batches)

Solubility

DMSO:40 mg/mL (108.58 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.43 mM)

Smiles

N=1N=C (C2=NOC (=C2) C) N3N=C (OCC4=NC=NN4C) C (=C3C1) C (C) (C) C

Molecular Formula

C17H20N8O2

Molecular Weight

368.39

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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