RIPK2/3 IN 29
Compound 29 is a potent dual inhibitor of RIPK2 (IC50=12 nM) and RIPK3 (IC50=18 nM) . It blocks NOD-driven cytokine release and necroptosis, demonstrating efficacy in a DSS-induced colitis mouse model, highlighting its research utility for studying inflammatory bowel disease (IBD) pathways.
Product Specifications
Field of Research
Cell Biology
Smiles
FC1=CC=CC=C1NC2=NC=NC3=CC (C4=CC=C (N5CCOCC5) N=C4) =CC=C32
Molecular Formula
C23H20FN5O
Molecular Weight
401.44
Storage Conditions
-20°C
Notes
For research use only.
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