RIPK2/3 IN 29

Compound 29 is a potent dual inhibitor of RIPK2 (IC50=12 nM) and RIPK3 (IC50=18 nM) . It blocks NOD-driven cytokine release and necroptosis, demonstrating efficacy in a DSS-induced colitis mouse model, highlighting its research utility for studying inflammatory bowel disease (IBD) pathways.