5- (N, N-Hexamethylene) -amiloride
5- (N, N-Hexamethylene) -amiloride (5-HMA) is an amiloride derivative that inhibits TRPA1-mediated calcium signaling (IC50: 35 μM) . It functions as an inhibitor of the Na+/H+ exchanger (NHE) with Ki values ranging from 0.013 to 2.4 μM for various NHE isoforms. Additionally, 5-HMA blocks ASIC3 channels by 51% at 20 μM.
Product Specifications
CAS Number
1428-95-1
Field of Research
Cell Biology, Infectious Disease & Virology, Neuroscience, Pharmacology & Drug Discovery, Protein Biochemistry
Purity
85.48% (May vary between batches)
Smiles
NC (=N) NC (=O) c1nc (Cl) c (nc1N) N1CCCCCC1
Molecular Formula
C12H18ClN7O
Molecular Weight
311.77
Storage Conditions
-20°C
Notes
For research use only.
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