PIT

PIT (2,2'-Pyridylisatogen tosylate) is a selective and non-competitive antagonist of P2Y1 receptor with an IC50 value of 0.14 μM for human P2Y1 receptor. PIT antagonizes P2Y1 receptor signaling without affecting nucleotide binding. PIT is an irreversible antagonist of responses to ATP at metabotropic purinoceptors (of the P2Y family) in some smooth muscles. PIT can be used for the research of chronic bronchitis and asthma[1][2][3].

Product Specifications

CAS Number

[56583-49-4]

Product Name Alternative

2,2'-Pyridylisatogen tosylate

UNSPSC

12352005

Target

P2Y Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cancer

Assay Protocol

https://www.medchemexpress.com/pit.html

Purity

99.07

Solubility

DMSO : 83.33 mg/mL (ultrasonic; warming; heat to 70°C)

Smiles

O=C1C(C2=NC=CC=C2)=[N+]([O-])C3=C1C=CC=C3.O=S(C4=CC=C(C)C=C4)(O)=O

Molecular Formula

C20H16N2O5S

Molecular Weight

396.42

References & Citations

[1]Gao ZG, et al. 2,2'-Pyridylisatogen tosylate antagonizes P2Y1 receptor signaling without affecting nucleotide binding. Biochem Pharmacol. 2004 Jul 15;68 (2) :231-7.|[2]King BF, et al. Potentiation by 2,2'-pyridylisatogen tosylate of ATP-responses at a recombinant P2Y1 purinoceptor. Br J Pharmacol. 1996 Mar;117 (6) :1111-8.|[3]Menton K, et al. Role of spin trapping and P2Y receptor antagonism in the neuroprotective effects of 2,2'-pyridylisatogen tosylate and related compounds. Eur J Pharmacol. 2002 May 24;444 (1-2) :53-60.