DT2216

DT2216 is a VHL-recruiting PROTAC that selectively degrades BCL-XL. It demonstrates potent activity against BCL-XL-dependent leukemia and cancer cell lines in vitro and in vivo, while showing reduced on-target toxicity to platelets compared to traditional inhibitors.

Product Specifications

CAS Number

2365172-42-3

Product Name Alternative

Apoptosis, DT 2216, DT2216, DT-2216, PROTAC, VHL

Field of Research

Cell Biology, Pharmacology & Drug Discovery

Purity

99.52% (May vary between batches)

Solubility

H2O:< 0.1 mg/mL (insoluble) ; DMSO:25 mg/mL (16.21 mM) ;10% DMSO+90% Corn Oil:2 mg/mL (1.3 mM)

Smiles

CC1 (C) CCC (C2=CC=C (Cl) C=C2) =C (C1) CN3CCN (C4=CC=C (C (NS (=O) (C5=CC (S (C (F) (F) F) (=O) =O) =C (N[C@@H] (CSC6=CC=CC=C6) CCN7CCN (C (CCCCCC (N[C@@H] (C (C) (C) C) C (N8[C@@H] (C[C@@H] (O) C8) C (N[C@H] (C9=CC=C (C%10=C (N=CS%10) C) C=C9) C) =O) =O) =O) =O) CC7) C=C5) =O) =O) C=C4) CC3