N-butyl Lithocholic Acid
This research-grade small molecule, N-butyl Lithocholic acid, is a derivative of lithocholic acid. When formulated into lipid nanoparticles for mRNA vaccine delivery, such as those encoding hemagglutinin, it demonstrates a reduced toxicity profile in mouse models compared to cholesterol-containing LNPs, showing lower cardiotoxicity and hepatosplenic effects. This makes it a valuable tool for investigating safer lipid nanoparticle systems in vaccinology and gene delivery research.
Product Specifications
CAS Number
135013-42-2
Field of Research
Metabolism Research
Smiles
C[C@@]12[C@] ([C@]3 ([C@@] ([C@]4 (C) [C@] (CC3) (C[C@H] (O) CC4) [H]) (CC1) [H]) [H]) (CC[C@@]2 ([C@@H] (CCC (OCCCC) =O) C) [H]) [H]
Molecular Formula
C28H48O3
Molecular Weight
432.68
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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