PKSI-527

PKSI-527 is a new, highly selective plasma kallikrein inhibitor. PKSI-527 can suppress collagen-induced arthritis (CIA) by modifying the kallikrein-kinin system[1].

Product Specifications

CAS Number

[128837-71-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Kallikrein

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/pksi-527.html

Concentration

10mM

Purity

95.39

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

NC[C@@H]1CC[C@H](CC1)C(N[C@H](C(NC2=CC=C(C=C2)CC(O)=O)=O)CC3=CC=CC=C3)=O.Cl

Molecular Formula

C25H32ClN3O4

Molecular Weight

473.99

Precautions

H302, H315, H319

References & Citations

[1]Fujimori Y, et al. Effects of a highly selective plasma kallikrein inhibitor on collagen-induced arthritis in mice. Agents Actions. 1993 May;39 (1-2) :42-8.