Sp-2-Cl-cAMPS
Product Specifications
CAS Number
124854-63-3
UNSPSC Description
Sp-2-Cl-cAMPS is an agonist for PKA with improved membrane permeability and stability to phosphodiesterase. Sp-2-Cl-cAMPS exhibits antimalarial activity, and inhibits the proliferation of Plasmodium falciparum with an EC50 of 4 μM. Sp-2-Cl-cAMPS binds to purified P. falciparum PfPKAr (regulatory subunit of PfPKA) with a Ki of 1.3 µM[1].
Target Antigen
Parasite; PKA
Type
Reference compound
Related Pathways
Anti-infection;Stem Cell/Wnt;TGF-beta/Smad
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/sp-2-cl-camps.html
Smiles
O[C@@H]1[C@H](O2)[C@@H](CO[P@@]2(S)=O)O[C@H]1N3C=NC4=C3N=C(Cl)N=C4N
Molecular Weight
379.72
References & Citations
[1]Lasonder E, et al., cAMP-Dependent Signaling Pathways as Potential Targets for Inhibition of Plasmodium falciparum Blood Stages. Front Microbiol. 2021 May 24;12:684005.
Shipping Conditions
Room temperature
Clinical Information
No Development Reported
Frequently Asked Questions
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