HH-2853
HH-2853 is a potent and selective dual EZH1/2 inhibitor with low nM IC50 values. It effectively reduces H3K27 methylation in cells and shows superior in vivo antitumor efficacy compared to tazemetostat in xenograft models with EZH2 mutations or SWI/SNF alterations, making it a valuable research tool for epigenetics and oncology studies.
Product Specifications
CAS Number
2202678-04-2
Smiles
O=C (NCC=1C (=O) NC (=CC1OC) C) C2=CC3=C (C=CN3C (=C2C) C (N4CCN (CC4) CC (F) (F) F) C) C5=NN=C (C=C5) C
Molecular Formula
C31H36F3N7O3
Molecular Weight
611.66
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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