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GDC-0134

GDC-0134 is a brain-penetrant, small-molecule inhibitor of dual leucine zipper kinase (DLK) that blocks downstream JNK activation to prevent neuronal degeneration. It is utilized in preclinical research for neurodegenerative diseases like ALS, with studies demonstrating neuroprotective effects in both cellular and animal models.

Product Specifications

CAS Number

1637394-01-4

Field of Research

Signal Transduction

Smiles

FC1 (F) CN (C=2N=C (C=C (N2) C=3C=C (OC (F) F) C (N) =NC3) N4[C@]5 (C[C@@] (C4) (OC5) [H]) [H]) CC1

Molecular Formula

C19H20F4N6O2

Molecular Weight

440.4

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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