GDC-0134
GDC-0134 is a brain-penetrant, small-molecule inhibitor of dual leucine zipper kinase (DLK) that blocks downstream JNK activation to prevent neuronal degeneration. It is utilized in preclinical research for neurodegenerative diseases like ALS, with studies demonstrating neuroprotective effects in both cellular and animal models.
Product Specifications
CAS Number
1637394-01-4
Field of Research
Signal Transduction
Smiles
FC1 (F) CN (C=2N=C (C=C (N2) C=3C=C (OC (F) F) C (N) =NC3) N4[C@]5 (C[C@@] (C4) (OC5) [H]) [H]) CC1
Molecular Formula
C19H20F4N6O2
Molecular Weight
440.4
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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