TD-004
TD-004 (HC58-111) is a potent ALK degrader that induces the degradation of ALK fusion proteins. It demonstrates robust anti-proliferative activity in ALK+ cell lines like SU-DHL-1 and H3122 and significantly inhibits tumor growth in H3122 xenograft models, supporting its use in oncology research for targeted protein degradation studies.
Product Specifications
CAS Number
2351915-38-1
Smiles
N (C1=C (OC (C) C) C=C (C (C) =C1) C2CCN (C (CCCC (N[C@H] (C (=O) N3[C@H] (C (NCC4=CC=C (C=C4) C5=C (C) N=CS5) =O) C[C@H] (O) C3) [C@] (C) (C) C) =O) =O) CC2) C=6N=C (NC7=C (S (C (C) C) (=O) =O) C=CC=C7) C (Cl) =CN6
Molecular Formula
C55H70ClN9O8S2
Molecular Weight
1084.78
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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