Adekalant
Adekalant (H 345/52) is a selective I (Kr) channel blocker with minimal proarrhythmic risk, effectively delaying cardiac repolarization by inhibiting HERG currents (IC50 230 nM) . Its favorable safety profile, characterized by reduced dispersion and absence of TdP induction, makes it a valuable research tool for in vitro and in vivo studies of arrhythmia mechanisms and antiarrhythmic drug development.
Product Specifications
CAS Number
227940-00-3
Smiles
C (OC (C) (C) C) (=O) N1CC2CC (C1) CN (C[C@@H] (COC3=CC=C (C#N) C=C3) O) C2
Molecular Formula
C22H31N3O4
Molecular Weight
401.5
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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