Adekalant

Adekalant (H 345/52) is a selective I (Kr) channel blocker with minimal proarrhythmic risk, effectively delaying cardiac repolarization by inhibiting HERG currents (IC50 230 nM) . Its favorable safety profile, characterized by reduced dispersion and absence of TdP induction, makes it a valuable research tool for in vitro and in vivo studies of arrhythmia mechanisms and antiarrhythmic drug development.