Abemaciclib
Abemaciclib (LY2835219) is a selective CDK4/6 inhibitor with IC50 values of 2 nM and 10 nM for CDK4 and CDK6, respectively.
Product Specifications
CAS Number
[1231929-97-7]
Product Name Alternative
LY2835219
UNSPSC
12352005
Hazard Statement
H360, H373, H410
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/LY2835219-free-base.html
Purity
99.97
Solubility
DMSO : 2.94 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
CC1=NC2=C(F)C=C(C3=NC(NC4=NC=C(CN5CCN(CC)CC5)C=C4)=NC=C3F)C=C2N1C(C)C
Molecular Formula
C27H32F2N8
Molecular Weight
506.59
Precautions
H360, H373, H410
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-16297A/Abemaciclib-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-16297A/Abemaciclib-SDS-MedChemExpress.pdf
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
CDK1; CDK2; CDK4; CDK5; CDK6; CDK7; CDK9
Citation 01
Available Sizes
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