M4K2281

M4K2281 is a potent and selective ALK2 inhibitor with a biochemical IC50 of 2 nM, demonstrating efficacy in cellular assays. Its moderate-to-high brain-to-plasma ratio supports its utility in researching ALK2-related pathologies, including fibrodysplasia ossificans progressiva (FOP), in both in vitro and in vivo experimental models.