Atenolol-d7

Atenolol-d7 is the deuterium labeled Atenolol. Atenolol ((RS) -Atenolol) is a cardioselective β1-adrenergic receptor blocker, with a Ki of 697 nM atβ1-adrenoceptor in guine pig left ventricle membrane. Atenolol can be used for the research of hypertension and angina pectoris[1][2].

Product Specifications

CAS Number

[1202864-50-3]

Product Name Alternative

(RS) -Atenolol-d7

UNSPSC

12352005

Hazard Statement

H225, H302, H312, H319, H332

Target

Adrenergic Receptor

Type

Isotope-Labeled Compounds

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease; Endocrinology

Purity

99.62

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 8.33mg/mL (ultrasonic)

Smiles

O=C(N)CC1=CC=C(OCC(O)CNC(C([2H])([2H])[2H])([2H])C([2H])([2H])[2H])C=C1

Molecular Formula

C14H15D7N2O3

Molecular Weight

273.38

Precautions

H225, H302, H312, H319, H332

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Heel RC, et al. Atenolol: a review of its pharmacological properties and therapeutic efficacy in angina pectoris and hypertension. Drugs. 1979;17 (6) :425-460.|[3]Engel G, et al. (+/-) [125Iodo] cyanopindolol, a new ligand for beta-adrenoceptors: identification and quantitation of subclasses of beta-adrenoceptors in guinea pig. Naunyn Schmiedebergs Arch Pharmacol. 1981;317 (4) :277-285.