MS40
MS40 is a WDR5-targeting PROTAC that acts as a novel IMiD degrader, inducing the degradation of CRBN neo-substrates IKZF1 and IKZF3. It disrupts the MLL complex, lowering H3K4me2 levels, and has demonstrated efficacy in inhibiting leukemia cell growth in vitro and suppressing patient-derived xenograft expansion in vivo.
Product Specifications
CAS Number
2407449-49-2
Smiles
O=C1C=C (C (=CN1) C (=O) NC2=CC (=CC=C2N3CCN (C) CC3) C=4C=CC=C (C4) CN5CCN (CCNC (=O) CCCCCCCNC6=CC=CC=7C (=O) N (C (=O) C67) C8C (=O) NC (=O) CC8) CC5) C (F) (F) F
Molecular Formula
C52H61F3N10O7
Molecular Weight
995.1
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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