MK256
MK256 is a potent and selective CDK8 inhibitor that suppresses the STAT pathway, reducing STAT1/5 phosphorylation and downstream targets like MCL-1. It demonstrates robust anti-AML activity by inducing differentiation and inhibiting proliferation, validated in both MOLM-14 cell lines and xenograft models.
Product Specifications
CAS Number
2271348-04-8
Smiles
O=C (O) C=1C=CC=2C (=CC (Br) =C3C=CN=C (N) C32) C1
Molecular Formula
C14H9BrN2O2
Molecular Weight
317.14
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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