S3QEL-2
S3QEL-2, a suppressor of superoxide production from mitochondrial complex III, potently and selectively suppresses site IIIQo superoxide production (IC50=1.7 μM) . S3QEL-2 does not affect oxidative phosphorylation, and normal electron flux. S3QEL-2 inhibits HIF-1α accumulation[1].
Product Specifications
CAS Number
[890888-12-7]
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Mitochondrial Metabolism; Oxidative Phosphorylation
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/s3qel-2.html
Concentration
10mM
Purity
99.62
Solubility
DMSO : 20.83 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CCCN(CCC)C1=C2C(N(C3=CC=C(C)C(C)=C3)N=C2)=NC=N1
Molecular Formula
C19H25N5
Molecular Weight
323.44
Precautions
H302, H315, H319
References & Citations
[1]Orr AL, et al. Suppressors of superoxide production from mitochondrial complex III. Nat Chem Biol. 2015;11 (11) :834-836.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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