Clesacostat tromethamine
PF-05221304 (Clesacostat) is a potent, selective ACC inhibitor with IC50 values of 13 nM and 9 nM for hACC1 and hACC2, respectively. It effectively suppresses hepatic de novo lipogenesis in vivo and has demonstrated a favorable safety profile regarding thrombocytopenia risk in non-human primate models, supporting its use in metabolic disease research.
Product Specifications
CAS Number
2334472-62-5
Smiles
O=C (O) C=1C=CC (=CC1) C2=NC (OC) =CC (=C2) C (=O) N3CCC4 (CC (=O) C5=C (C=NN5C (C) C) C4) CC3.OCC (N) (CO) CO
Molecular Formula
C32H41N5O8
Molecular Weight
623.7
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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