SKF 83822

SKF 83822 is an atypical agonist of dopamine D1 receptor. SKF 83822 activates adenylyl cyclase (AC), but not phospholipase C (PLC) . SKF 83822 is also proved to stimulate AC via cAMP production. SKF 83822 can be used for research of schizophrenia[1][2].

Product Specifications

CAS Number

[74115-08-5]

UNSPSC

12352005

Hazard Statement

H301, H315, H319, H335, H400

Target

Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/skf-83822.html

Purity

98.01

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC1=C(C=C2C(CN(CCC2=C1Cl)CC=C)C3=CC=CC(C)=C3)O

Molecular Formula

C20H22ClNO2

Molecular Weight

343.85

Precautions

H301, H315, H319, H335, H400

References & Citations

[1]Wirtshafter D. Rotation and immediate-early gene expression in rats treated with the atypical D1 dopamine agonist SKF 83822. Pharmacol Biochem Behav. 2007 Mar;86 (3) :505-10. |[2]Peacock L, et al. Aberrant behavioral effects of a dopamine D1 receptor antagonist and agonist in monkeys: evidence of uncharted dopamine D1 receptor actions. Biol Psychiatry. 2001 Oct 1;50 (7) :501-9.