LC-04-045
LC-04-045 is a potent and selective molecular glue degrader targeting NEK7, achieving 90% degradation at 7 nM in MOLT-4 cells via the UPS. It effectively inhibits IL-1β and IL-18 secretion, making it a valuable tool for studying NLRP3 inflammasome biology and inflammatory disease mechanisms.
Product Specifications
Field of Research
Immunology & Inflammation, Signal Transduction
Molecular Formula
C32H28ClN5O3
Molecular Weight
566.05
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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