FGFRs-IN-1

FGFRs-IN-1 (A16) is a potent, orally active multi-kinase inhibitor primarily targeting FGFR1-4, with additional activity against VEGFRs, Abl, and Flt3. It suppresses fibrosis-related markers like α-SMA and collagen I, inhibits TGF-β1-induced EMT in vitro, and demonstrates anti-fibrotic efficacy in mouse models of lung and liver fibrosis.