Proteasome-IN-7

Proteasome-IN-7 (Compound 6f) is a macrolactam epoxyketone inhibitor of the 20S proteasome's ChT-L activity (IC50 = 37.92 nM) . It demonstrates robust in vitro antiproliferative activity against hematological and solid tumor cell lines, including multiple myeloma and non-small cell lung cancer, supporting its use in oncology research.