SMD-3236
SMD-3236 is a potent and selective SMARCA2 PROTAC degrader, demonstrating high selectivity over SMARCA4 and robust anti-tumor efficacy in SMARCA4-deficient xenograft models like H838. This compound is a valuable chemical probe for researching synthetic lethality in oncology, supporting both in vitro mechanism of action studies and in vivo preclinical investigations.
Product Specifications
CAS Number
3033586-31-8
Field of Research
Epigenetics & Chromatin, Pharmacology & Drug Discovery
Smiles
O=C1N=C2C3 (C=4C (N2C=5C1=C (Cl) C=CC5) =CC (=CC4) C6CCN (C[C@H]7CC[C@@H] (CC7) C8=CN ([C@H] (C (=O) N9[C@H] (C (N[C@@H] (CN%10CCOCC%10) C%11=CC=C (C=C%11) C=%12SC=NC%12C) =O) C[C@@H] (O) C9) C (C) (C) C) N=N8) CC6) CCCCC3
Molecular Formula
C61H75ClN10O5S
Molecular Weight
1095.83
Storage Conditions
-20°C
Notes
For research use only.
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