PPARα/δ agonist 3
Compound 8 is a potent, orally bioavailable pan-PPAR agonist with EC50 values of 5.6 nM (PPARα), 3.4 nM (PPARδ), and 1278 nM (PPARγ) . It demonstrates anti-cholestatic efficacy in vivo using ANIT- and CDCA-induced mouse models, supporting research into metabolic and liver diseases.
Product Specifications
CAS Number
3050611-33-8
Field of Research
Metabolism Research, Molecular Biology, Pharmacology & Drug Discovery
Smiles
O=C (O) C (OC=1C (=CC (=CC1C) CN2C (=O) N (C3=CC=C (C=C3) C (F) (F) F) CC2) C) (C) C
Molecular Formula
C23H25F3N2O4
Molecular Weight
450.451
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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