GSK3β-IN-2
GSK3β-IN-2 (S01) is a potent GSK3β inhibitor (IC50 = 0.35 nM) that activates Wnt/β-catenin signaling to promote neurogenesis. It reduces Aβ-induced tau phosphorylation at Ser396, decreasing neurofibrillary tangles, and has been shown to ameliorate Alzheimer's-related phenotypes in a zebrafish model.
Product Specifications
CAS Number
3068378-38-8
Field of Research
Signal Transduction, Stem Cell & Developmental Biology
Smiles
O=C (NC=1C=NC=CC1C=2C=CC=CC2) C3=CNC4=NC=C (C=C43) C=5C=CC=CC5
Molecular Formula
C25H18N4O
Molecular Weight
390.437
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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040031-Biotin 200 µL
PIGP, NT (PIGP, DCRC, DSCR5, DSCRC, Phosphatidylinositol N-acetylglucosaminyltransferase subunit P, Down syndrome critical region protein 5, Down syndrome critical region protein C, Phosphatidylinositol-glycan biosynthesis class P protein) (Biotin) discontinued
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