Topo I/II-IN-2
Topo I/II-IN-2 (Compound 3g) is a dual topoisomerase I/II inhibitor that induces mitochondrial apoptosis and inhibits the PI3K/Akt/mTOR pathway. It demonstrates anti-proliferative activity against SCLC cell lines (e.g., NCI-H446, IC50=1.30 μM) in vitro, supporting its investigation as a potential chemotherapeutic agent in cancer research.
Product Specifications
Field of Research
Cell Biology, Metabolism Research, Molecular Biology, Protein Biochemistry, Signal Transduction
Molecular Formula
C25H26N2O4
Molecular Weight
418.48
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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