Duostatin 5.3

Duostatin 5.3 (DUO 5.3) is a synthetic analog of a natural dolastatin, designed for use as a potent cytotoxic warhead in antibody-drug conjugates (ADCs) . Its application is primarily in oncology research, where it is investigated in vitro and in vivo for its microtubule-disrupting and antitumor activities.