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Isoxsuprine hydrochloride

Isoxsuprine hydrochloride is a beta-adrenergic receptor agonist with Kis of 13.65 μΜ and 3.48 μΜ for myometrial and placcntal beta-adrenergic receptor, respectively. Isoxsuprine hydrochloride is also a NMDA receptor antagonist.

Product Specifications

CAS Number

579-56-6

UNSPSC

12352005

Hazard Statement

H302, H410

Target

Adrenergic Receptor; iGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/Isoxsuprine_hydrochloride.html

Purity

99.95

Solubility

DMSO : 116.67 mg/mL (ultrasonic) |H2O : 15.56 mg/mL (ultrasonic)

Smiles

OC(C(NC(C)COC1=CC=CC=C1)C)C2=CC=C(O)C=C2.[H]Cl

Molecular Formula

C18H24ClNO3

Molecular Weight

337.85

Precautions

H302, H410

References & Citations

[1]Falkay G, et al. Affinity of tocolytic agents on human placental and myometrial beta-adrenergic receptors. J Perinat Med. 1986;14 (2) :109-13.|[2]Kretschy N, et al. In vitro inhibition of breast cancer spheroid-induced lymphendothelial defects resembling intravasation into the lymphatic vasculature by acetohexamide, isoxsuprine, nifedipin and proadifen. Br J Cancer. 2013 Feb 19;108 (3) :570-8.|[3]Hill JW, et al. Identification of isoxsuprine hydrochloride as a neuroprotectant in ischemic stroke through cell-based high-throughput screening. PLoS One. 2014 May 7;9 (5) :e96761.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

NMDA Receptor

Available Sizes

Frequently Asked Questions

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