T6167923 B
T6167923 is a selective inhibitor of MyD88-dependent signaling pathways. T6167923 directly binds to Toll/IL1 receptor (TIR) domain of MyD88 and disrupts MyD88 homodimeric formation. T6167923 inhibits NF-κB driven Staphylococcus enterotoxin AP (SEAP) activity, and improves anti-inflammatory activity with IC50s of 2.7 μM, 2.9 μM, 2.66 μM and 2.66 μM for IFN-γ, IL-1β, IL-6 and TNF-α, respectively.
Product Specifications
CAS Number
2437475-16-4
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 250 mg/mL (545.39 mM; Ultrasonic) H2O : < 0.1 mg/mL (insoluble)
Smiles
C[C@H] (NC (=O) N1CCN (CC1) S (=O) (=O) c1cccc (Br) c1) c1cccs1
Molecular Formula
C17H20BrN3O3S2
Molecular Weight
458.39
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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