TC-I 2014
TC-I 2014 (compound 5) is a potent and orally active Benzimidazole-containing transient receptor potential melastatin 8 (TRPM8) antagonist, with IC50 values of 0.8 nM, 3.0 nM and 4.4 nM for canine, human and rat channels respectively. TC-I 2014 exhibits antiallodynic properties in pain models.
Product Specifications
CAS Number
1221349-53-6
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 250 mg/mL (534.86 mM; Ultrasonic)
Smiles
FC (F) (F) c1ccccc1-c1cc (c2[nH]c (nc2c1) C1=NOC2 (C1) CCCCC2) C (F) (F) F
Molecular Formula
C23H19F6N3O
Molecular Weight
467.41
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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