GSK-3 inhibitor 4
GSK-3 inhibitor 4 is an orally active and brain-penetrant inhibitor of GSK-3, CDK2, and CDK5, with IC50 values of 0.56 nM (GSK-3β), 0.45 nM (GSK-3α), 0.47 μM, and 0.68 μM, respectively. GSK-3 inhibitor 4 effectively reduces the phosphorylation level of Tau protein. GSK-3 inhibitor 4 can be used in Alzheimer's disease (AD) studies.
Product Specifications
CAS Number
2227279-83-4
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Smiles
N (C (=O) C1=NC (NC2=CC=C (F) C=C2) =NC=C1) C=3C (=CC=NC3) C4=CC=C (F) C=C4
Molecular Formula
C22H15F2N5O
Molecular Weight
403.38
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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