Nrf2-IN-3
Nrf2-IN-3 (Compound R16) is a Nrf2 inhibitor. Nrf2-IN-3 binds KEAP1 mutants (G333C mKEAP1) and repairs the disrupted KEAP1/NRF2 interactions. Nrf2-IN-3 sensitizes KEAP1-mutated cancer cells to Cisplatin (HY-17394) and Gefitinib (HY-50895) by repairing the mKEAP1/NRF2 complex.
Product Specifications
CAS Number
6325-13-9
Purity
>98% (HPLC)
Smiles
O=C (NN=CC=1C=CC=CC1O) CCCSCCCC (=O) NN=CC=2C=CC=CC2O
Molecular Formula
C22H26N4O4S
Molecular Weight
442.53
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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