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PF-4942847

PF-4942847 is a novel, orally bioavailable Hsp90 inhibitor under investigation for triple-negative breast cancer (TNBC) due to its synergistic disruption of multiple oncogenic pathways. Its mechanism, demonstrated in vitro and in vivo, includes inducing AKT degradation in peripheral blood lymphocytes, a potential pharmacodynamic biomarker for clinical trials.

Product Specifications

CAS Number

1046859-34-0

Smiles

O=C (NCC (F) (F) F) N1CC=2N=C (N=C (C=3C (Cl) =CC (Cl) =CC3OCCN4N=CC=C4) C2C1) N

Molecular Formula

C20H18Cl2F3N7O2

Molecular Weight

516.3

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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