QZ2135
QZ2135 (compound 20) is a potent and selective RET-targeting PROTAC degrader, effective against wild-type and mutant (V804M, G810C) RET fusions. It demonstrates in vivo antitumor activity in a Ba/F3-KIF5B-RET-G810C xenograft model, supporting its application in oncology research for studying RET-driven cancers and targeted protein degradation.
Product Specifications
Field of Research
Cell Biology, Pharmacology & Drug Discovery, Signal Transduction
Molecular Formula
C53H54N12O4
Molecular Weight
923.07
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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