SD-436
SD-436 is a potent and selective STAT3-targeting PROTAC degrader with a DC50 of 0.5 μM. It demonstrates high selectivity over other STAT family members and has been shown to induce tumor regression in mouse models of leukemia and lymphoma, supporting its use in oncology and signal transduction research.
Product Specifications
CAS Number
2497585-50-7
Product Name Alternative
SD436
Field of Research
Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology
Purity
99.34% (May vary between batches)
Smiles
C (#CCCC1CCN (C ([C@H] (CC2=CC (F) =C (F) C=C2) NC ([C@@H] (NC (=O) [C@H]3N4[C@] (CC3) (CCN (C (OC) =O) C[C@H] (NC (=O) C5=CC=6C (S5) =CC=C (C (P (=O) (O) O) (F) F) C6) C4=O) [H]) CCC (N) =O) =O) =O) CC1) C7=C8C (C (=O) N (C8) C9C (=O) NC (=O) CC9) =CC=C7
Molecular Formula
C58H62F4N9O14PS
Molecular Weight
1248.2
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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