SD-436

SD-436 is a potent and selective STAT3-targeting PROTAC degrader with a DC50 of 0.5 μM. It demonstrates high selectivity over other STAT family members and has been shown to induce tumor regression in mouse models of leukemia and lymphoma, supporting its use in oncology and signal transduction research.

Product Specifications

CAS Number

2497585-50-7

Product Name Alternative

SD436

Field of Research

Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology

Purity

99.34% (May vary between batches)

Smiles

C (#CCCC1CCN (C ([C@H] (CC2=CC (F) =C (F) C=C2) NC ([C@@H] (NC (=O) [C@H]3N4[C@] (CC3) (CCN (C (OC) =O) C[C@H] (NC (=O) C5=CC=6C (S5) =CC=C (C (P (=O) (O) O) (F) F) C6) C4=O) [H]) CCC (N) =O) =O) =O) CC1) C7=C8C (C (=O) N (C8) C9C (=O) NC (=O) CC9) =CC=C7