MI-1063
MI-1063 is a potent and cell-permeable MDM2 antagonist that disrupts the MDM2-p53 interaction, leading to p53 activation and tumor suppression. It demonstrates anti-proliferative activity in hematological cancer cell lines (e.g., RS4-11, MV4-11) and serves as the warhead for the PROTAC degrader MD-265 in oncology research.
Product Specifications
CAS Number
1410737-39-1
Field of Research
Cell Biology, Pharmacology & Drug Discovery
Smiles
O=C1[C@@]2 (C3 (N[C@@H] (C (N[C@H]4CC[C@H] (C (O) =O) CC4) =O) [C@@H]2C5=C (F) C (Cl) =CC=C5) CCCCC3) C=6C (N1) =CC (Cl) =CC6
Molecular Formula
C30H32Cl2FN3O4
Molecular Weight
588.5
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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