UP163
UP163 is a small molecule activator of valosin-containing protein (VCP), enhancing its ATPase activity with an EC50 of 9.0 μM. It has been shown in cellular models to reduce proteasome inhibitor-induced TDP-43 aggregation, making it a useful research tool for studying proteinopathies and VCP-related pathways in vitro.
Product Specifications
CAS Number
591242-60-3
Field of Research
Protein Biochemistry
Smiles
O=C (OCCN (C1=CC=C (Cl) C=C1) C2=NS (=O) (=O) C=3C=CC=CC23) C=4OC=CC4
Molecular Formula
C20H15ClN2O5S
Molecular Weight
430.86
Storage Conditions
-20°C
Notes
For research use only.
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