PDE1-IN-8
PDE1-IN-8 (Compound 3f) is a potent PDE1 inhibitor (IC50 = 11 nM) that suppresses cAMP and cGMP hydrolysis. This action blocks myofibroblast differentiation and proliferation, providing antifibrotic efficacy validated in a Bleomycin-induced rat model of pulmonary fibrosis. It is a valuable research tool for studying fibrosis and PDE1 signaling pathways.
Product Specifications
Field of Research
Metabolism Research
Molecular Formula
C17H11Cl2N3OS2
Molecular Weight
408.32
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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P9104-92F 200 µL
PRKRA, phosphorylated (Ser246) (Interferon-inducible Double Stranded RNA-dependent Protein Kinase Activator A, Protein Kinase, Interferon-inducible Double Stranded RNA-dependent Activator, Protein Activator Of The Interferon-induced Protein Kinase, PKR-associated Protein X, PKR-associating Protein X, HSD14, HSD-14, PACT, RAX)
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