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FAK-IN-22

FAK-IN-22 (Compound 26) is a potent multi-kinase inhibitor targeting FAK, JAK3, and Aurora B (IC50s: 50.94, 9.99, and 0.49 nM, respectively) . It suppresses pancreatic cancer (PDAC) proliferation, metastasis, and tumorigenesis in vitro and in vivo by inducing apoptosis and G2/M arrest via FAK/PI3K/Akt pathway inhibition.

Product Specifications

CAS Number

2703920-02-7

Field of Research

Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Smiles

O=C (NC) C1=CC=C (C=C1) NC2=NC=C (C (=N2) OC3=CC=CC=4NC=CC34) C (F) (F) F

Molecular Formula

C21H16F3N5O2

Molecular Weight

427.38

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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